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  • Title: Reversed-phase high-performance liquid chromatographic assay for the simultaneous determination of diflunisal and its glucuronides in serum and urine. Rearrangement of the 1-O-acylglucuronide.
    Author: Hansen-Møller J, Dalgaard L, Hansen SH.
    Journal: J Chromatogr; 1987 Sep 04; 420(1):99-109. PubMed ID: 3667833.
    Abstract:
    A reversed-phase ion-pair high-performance liquid chromatographic assay for the simultaneous determination of diflunisal and its ester and ether glucuronide in urine and serum has been developed. The determination of the ester glucuronide in serum has not been previously reported. The genuine glucuronide conjugates isolated from urine were used as standards. The ester glucuronide is found to be unstable, especially in neutral and basic solutions, and special precautions therefore have to be taken during sampling and sample treatment. Nine rearrangement/degradation products of the ester glucuronide were detected.
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