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  • Title: Movement of calcium ions and their role in the activation of platelets.
    Author: Massini P, Käser-Glanzmann R, Lüscher EF.
    Journal: Thromb Haemost; 1978 Oct 31; 40(2):212-8. PubMed ID: 366792.
    Abstract:
    The increase of the cytoplasmic Ca-concentration plays a central role in the initiation of platelet activation. Four kinds of movements of Ca-ions are presumed to occur during this process: a) Ca-ions liberated from membranes induce the rapid shape change. b) Vesicular organelles release Ca-ions into the cytoplasm which initiate the release reaction. c) The storage organelles called dense bodies, secrete their contents including Ca-ions to the outside during the release reaction. d) At the same time a rearrangement of the plasma membrane occurs, resulting in an increase in its permeability for Ca-ions as well as in an increase in the number of Ca-binding sites. Since most processes occurring during platelet activation are reversible, the platelet must be equipped with a mechanism which removes Ca-ions from the cytoplasm. A vesicular fraction obtained from homogenized platelets indeed accumulates Ca actively. This Ca-pump is stimulated by cyclic AMP and protein kinase; it may be involved in the recovery of platelets after activation.
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