These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Use of 1 alpha-hydroxyvitamin D3 in the prevention of bovine parturient paresis. IX. Early and late effects of a single injection.
    Author: Sachs M, Perlman R, Bar A.
    Journal: J Dairy Sci; 1987 Aug; 70(8):1671-5. PubMed ID: 3668037.
    Abstract:
    Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1 alpha-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 micrograms 1 alpha-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 micrograms 1 alpha-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 micrograms 1 alpha-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 micrograms 1 alpha-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving.
    [Abstract] [Full Text] [Related] [New Search]