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  • Title: Evidence of "cross-stressor"-induced adaptive gastric cytoprotection.
    Author: Glavin GB, Lockhart LK, Rockman GE, Hall AM, Kiernan KM.
    Journal: Life Sci; 1987 Nov 09; 41(19):2223-7. PubMed ID: 3669921.
    Abstract:
    Rats were given 7 days pre-treatment with either water (p.o.), 1 h immobilization or 20% ethanol (p.o.) with or without concomitant indomethacin injection. Following the pre-treatment phase, rats from each pre-treatment group were exposed to either 3 h cold-restraint stress or to 100% ethanol p.o. Results indicated that immobilization and 20% ethanol pre-treatment significantly reduced both cold-restraint stress ulcer formation and 100% ethanol-induced ulcers. Indomethacin co-treatment attenuated the reduction of ulcer formation of both pretreatments. These results suggest that "cross-stressor" adaptive cytoprotection occurs. Indomethacin abolished these effects, implicating the involvement of endogenous prostaglandins in the mediation of "cross-stressor"-induced gastric cytoprotection.
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