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  • Title: Synthesis and antimycotic activity of some benzyloxyimino compounds.
    Author: Garuti L, Giovanninetti G, Ferranti A, Chiarini A, Bertocchi G, Sabatino P, Brigidi P.
    Journal: Pharmazie; 1987 Jun; 42(6):378-81. PubMed ID: 3671457.
    Abstract:
    Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
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