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  • Title: The influence of propranolol and glucagon on the pharmacokinetics of antipyrine and sodium salicylate.
    Author: Orszulak-Michalak D, Kaszubski P.
    Journal: Pharmazie; 1987 Jun; 42(6):394-6. PubMed ID: 3671460.
    Abstract:
    Propranolol (1) decreases hepatic blood flow and glucagon (2) exerts an opposite effect on hepatic circulation. The effects of these drugs on the pharmacokinetics of phenazone (3; antipyrine)-a compound with low coefficient of hepatic extraction, and sodium salicylate (4) that is highly extracted by liver, were studied on rabbits. It was shown that changes in the pharmacokinetics of 3 and 4 in the presence of 1 or 2, seemed to be interactions between these drugs in the haemodynamic phase.
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