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  • Title: Estimation of intravoxel incoherent motion (IVIM) parameters in vertebral bone marrow: a comparative study of five algorithms.
    Author: Liu J, Karfoul A, Marage L, Shu H, Gambarota G.
    Journal: MAGMA; 2023 Oct; 36(5):837-847. PubMed ID: 36715885.
    Abstract:
    OBJECTIVES: To access the performances of different algorithms for quantification of Intravoxel incoherent motion (IVIM) parameters D, f, [Formula: see text] in Vertebral Bone Marrow (VBM). MATERIALS AND METHODS: Five algorithms were studied: four deterministic algorithms (the One-Step and three segmented methods: Two-Step, Three-Step, and Fixed-[Formula: see text] algorithm) based on the least-squares (LSQ) method and a Bayesian probabilistic algorithm. Numerical simulations and quantification of IVIM parameters D, f, [Formula: see text] in vivo in vertebral bone marrow, were done on six healthy volunteers. The One-way repeated-measures analysis of variance (ANOVA) followed by Bonferroni's multiple comparison test (p value = 0.05) was applied. RESULTS: In numerical simulations, the Bayesian algorithm provided the best estimation of D, f, [Formula: see text] compared to the deterministic algorithms. In vivo VBM-IVIM, the values of D and f estimated by the Bayesian algorithm were close to those of the One-Step method, in contrast to the three segmented methods. DISCUSSION: The comparison of the five algorithms indicates that the Bayesian algorithm provides the best estimation of VBM-IVIM parameters, in both numerical simulations and in vivo data.
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