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  • Title: [Simultaneous estimation of phenobarbitone and valproic acid in the plasma by high performance liquid chromatography (author's transl)].
    Author: Farinotti R, Pfaff MC, Mahuzier G.
    Journal: Ann Biol Clin (Paris); 1978; 36(4):347-53. PubMed ID: 367228.
    Abstract:
    The authors describe a method of simultaneous estimation of phenobarbitone and valproic acid in the blood. After extraction with ether, these substances were estimated by high performance liquid chromatography. They were separated on a mu Bondapack C18 column. The detection involved a colorimetric procedure based on variation in colour of a solution of bromocresol purple. The technic used is simple, its reproducibility is satisfactory (coefficients of variation of 7.6% for phenobarbitone and 2.3% for valproic acid). The sensitivity was 13.8 mumol/l for phenobarbitone and 11.1 mumol/l for valproic acid. Parallel estimations by gas chromatography led to comparable results. This method is of interest in the supervision of anticonvulsant treatments, especially in pediatrics.
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