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  • Title: Adaptation to hypoxia.
    Author: Longmuir IS.
    Journal: Adv Exp Med Biol; 1987; 215():249-54. PubMed ID: 3673723.
    Abstract:
    Many biochemical changes occur during acclimation to altitude. Some appear to be deleterious, but the increase in cytochrome-P 450 and the changes in the endoplasmic reticulum seem to be beneficial. The latter changes could reduce the capillary to oxidase gradient to compensate for the lower capillary oxygen tensions. The possibility of accelerating acclimation to hypoxia by using drugs which produce similar changes is being explored.
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