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  • Title: A long-wavelength mitochondria-targeted fluorescent probe for imaging of peroxynitrite during dexamethasone treatment.
    Author: Tang J, Li Z, Qiang C, Han Y, Yang L, Zhu L, Dang T, Chen G, Ye Y.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2023 May 05; 292():122429. PubMed ID: 36750010.
    Abstract:
    Peroxynitrite (ONOO-), as a strong oxidizing reactive nitrogen substance (RNS), is generated endogenously by cells. Its visualization research is crucial to understand relevant disease processes. Herein, we reported a long-wavelength mitochondria-targeted fluorescence "turn on" probe TL. The probe TL could react with ONOO- by using 4-(Bromomethyl)benzeneboronic as a reactive site, which exhibited outstanding characteristics for detection of ONOO-, thus improving response time (about 50 s), sensitivity (DL, 10.1 nM), and emission wavelength (667 nm). Besides, TL displayed well mitochondria targeting and biological visualizing of exogenous and endogenous ONOO- in biological systems. Finally, TL was used to monitor high concentration of dexamethasone-induced an up-regulation of ONOO-. This indicated that TL has excellent potential to study the fluctuation of ONOO- in the physiological and pathological system.
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