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  • Title: Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls.
    Author: Zohar J, Mueller EA, Insel TR, Zohar-Kadouch RC, Murphy DL.
    Journal: Arch Gen Psychiatry; 1987 Nov; 44(11):946-51. PubMed ID: 3675134.
    Abstract:
    To examine the "serotonin hypothesis" of obsessive-compulsive disorder (OCD), we studied the behavioral and neuroendocrine effects of metachlorophenylpiperazine (mCPP), a serotonergic agonist, in patients with OCD and healthy controls. Twelve patients and 20 controls were given a single dose of 0.5 mg/kg of mCPP, administered orally under double-blind, placebo-controlled, random-assignment conditions. Following mCPP, but not following placebo, patients with OCD experienced a transient but marked exacerbation of obsessive-compulsive symptoms. Moreover, compared with healthy controls, patients exhibited greater other behavioral (but not endocrinologic or thermal) changes after mCPP. These findings are consistent with a special role for the neurotransmitter serotonin in OCD psychopathology.
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