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  • Title: Histamine stimulates inositol phosphate accumulation via the H1-receptor in cultured human endothelial cells.
    Author: Lo WW, Fan TP.
    Journal: Biochem Biophys Res Commun; 1987 Oct 14; 148(1):47-53. PubMed ID: 3675593.
    Abstract:
    The effects of histamine on [3H]inositol phosphate ([3H]IP) accumulation was examined in the presence of lithium in [3H]inositol-prelabelled human umbilical vein endothelial cells. Histamine stimulated total [3H]IP formation in a dose-dependent manner with a half-maximal value (EC50) of around 1-2 X 10(-6) M. Mepyramine, but not cimetidine, completely abolished the histamine response indicating that activation of phosphoinositide hydrolysis is mediated via H1-receptors. These data are the first to suggest that activation of inositol lipid hydrolysis is the underlying transmembrane signalling mechanism histamine H1-receptors employ in mediating various endothelial cell functions.
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