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  • Title: [Characteristics of Na+/H+ metabolism in the erythrocytes of rats with spontaneous hypertension].
    Author: Pokudin NI, Orlov SN, Postnov IuV.
    Journal: Biull Eksp Biol Med; 1987 Oct; 104(10):416-8. PubMed ID: 3676456.
    Abstract:
    The dependence of the rate of valinomycin-induced Na+/H+ erythrocyte metabolism on the extracellular K+ concentration has been investigated. It has been established that Na+/H+ metabolism in the erythrocytes of spontaneously hypertensive rats (SHR) is induced at higher [K+]o concentrations than in normotensive controls (WKY). The distinctions in the maximum rate of Na+/H+ metabolism were revealed only in SHR in pre-hypertensive stage (it was 20% lower than in WKY). It is suggested that the distinctions are determined by peculiarities of membrane cytoskeleton formation. The conclusion was confirmed in experiments on erythrocyte stability to orthovanadate effect.
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