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  • Title: [Effect of tageflar, a synthetic analog of L-enkephalin, on the morphogenesis of experimental pancreatitis].
    Author: Kanaian AS, Permiakov NK, Titova GP, Golovleva GM, Arabadzhian KP.
    Journal: Biull Eksp Biol Med; 1987 Nov; 104(11):599-602. PubMed ID: 3676499.
    Abstract:
    It has been substantiated that the use of a new synthetic drug tageflar analogous to L-enkephalin was accompanied by the depression in pancreatic enzyme activity in the blood of rats, acceleration of necrotic and lytic processes in irreversibly damaged exocrine pancreocytes in the course of experimental pancreatitis. The drug promoted microcirculation retention in the injury zone and acceleration of the arrangement and elimination of necrotic glandular tissue. The influence of tagaflar diminished the extent of perifocal necrobiotic zone and suppressed sclerotic processes and pancreatic lipomatosis.
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