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  • Title: Diazepam dissociates the analgesic and aversive effects of periaqueductal gray stimulation in the rat.
    Author: Morgan MM, Depaulis A, Liebeskind JC.
    Journal: Brain Res; 1987 Oct 13; 423(1-2):395-8. PubMed ID: 3676817.
    Abstract:
    Electrical stimulation of the periaqueductal gray matter (PAG) of the rat can produce both analgesia and aversive reactions. To determine if these two effects can be dissociated, diazepam, a benzodiazepine, was administered to rats chronically implanted with electrodes in the PAG. The threshold for stimulation-produced analgesia or aversion, whichever was lowest, was determined before and after drug administration. Diazepam (1 mg/kg) attenuated stimulation-produced aversive reactions at 12 of 20 stimulation sites, allowing analgesia to be measured at the same threshold. Diazepam did not alter baseline pain sensitivity or thresholds for stimulation-produced analgesia. These results indicate that aversive reactions and analgesia from PAG stimulation can be pharmacologically dissociated.
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