These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Enhanced Purkinje cell survival in granuloprival cerebellar cultures.
    Author: Seil FJ.
    Journal: Brain Res; 1987 Oct; 432(2):312-6. PubMed ID: 3676846.
    Abstract:
    The number of large cortical neurons that survived in cerebellar cultures in which granule cells had been destroyed by exposure to cytosine arabinoside was 3-4 times the number in normal cultures. Transplantation of granuloprival cerebellar cultures with granule cells and glia resulted in a reduction of the large cortical neuron population (predominantly Purkinje cells) to normal, while the number of such neurons remained elevated after transplantation with glia alone. These results indicated that granule cells were critical for the reduction of large cortical neurons. The rescue of large cortical neurons in granuloprival cultures was attributed to an expanded target field for Purkinje cell axon collateral projections.
    [Abstract] [Full Text] [Related] [New Search]