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  • Title: IP3Rs puff along: A SNAPpy dance with IP3 and Ca2.
    Author: Nakhe AY, Jacobson DA.
    Journal: J Biol Chem; 2023 Mar; 299(3):103010. PubMed ID: 36773801.
    Abstract:
    Concerted openings of clustered inositol 1,4,5-trisphosphate receptors (IP3Rs) result in short, localized Ca2+ bursts, also called puffs, which are crucial regulators of Ca2+-dependent signaling processes. However, the processes regulating Ca2+ puff amplitude (average ∼0.5 ΔF/F0) and duration (at half-maximal; average ∼25-30 ms) have yet to be elucidated. A recent study in JBC by Smith and Taylor determined that Ca2+ puff amplitude is independent of IP3R cluster density and that the termination of IP3R Ca2+ puff is regulated by IP3 dissociation, illuminating the steps of this regulatory dance.
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