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  • Title: Hemoglobin J-Baltimore (beta 16(A13)Gly----Asp): interference with the assay of HbA1c.
    Author: Vandenesch F, Baklouti F, Francina A, Vianey-Liaud C, Bertrand A, Le Dévéhat C, Delaunay J.
    Journal: Clin Chim Acta; 1987 Sep 30; 168(2):121-8. PubMed ID: 3677411.
    Abstract:
    Three independent cases of Hemoglobin J-Baltimore(beta 16(A13)Gly----Asp) were detected through the assay of HbA1c in diabetic patients. Using chromatography on Bio-Rex 70 resin, one large peak replaced the usually well resolved peaks of HbA1a + b and HbA1c. The species that overlapped the latter fractions was identified as HbJ1c. HbJ-Baltimore itself was identified using HPLC of the beta-chain tryptic peptides. This observation emphasizes the errors that hemoglobin variants may introduce in the assay of HbA1c.
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