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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Immune-mediated hemolytic anemia induced by penicillin in horses.
    Author: Blue JT, Dinsmore RP, Anderson KL.
    Journal: Cornell Vet; 1987 Jul; 77(3):263-76. PubMed ID: 3677710.
    Abstract:
    Three horses developed severe, immune-mediated hemolytic anemia after treatment with penicillin. The horses had positive direct antiglobulin (Coombs) tests and high titers of IgG antibody that agglutinated penicillin-coated equine red cells. Two of the horses were tested for antibodies to autologous red cell antigens; autoantibodies were not present. Titers of antipenicillin antibody decreased after penicillin was discontinued but IgG antibody was detectable months after recovery. One of the horses was challenged with penicillin; antibody titer increased slightly, but anemia did not develop. Antipenicillin antibody of the IgM class was present in low titer in 23 (77%) of 30 non-anemic horses tested. Apparently, the horse is similar to man in that penicillin-induced anemia is rare but the percentage of individuals with antipenicillin antibody is high.
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