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  • Title: Evaluation of molluscicidal activity on Biomphalaria glabrata (Say, 1818) and phytochemical characterization of hydroalcoholic extract of leaves of Ricinus communis L. (EUPHORBIACEAE).
    Author: Nogueira AJL, Mendes RJA, França Nino CRC, Oliveira YDS, da Rocha CQ, Ambrósio HTMJ, Everton GO, Garros Rosa I, Pereira Filho AA.
    Journal: Exp Parasitol; 2023 Apr; 247():108481. PubMed ID: 36780972.
    Abstract:
    Schistosomiasis is a parasitic infection of great prevalence worldwide, affecting 250 million people in 78 countries. Faced with this problem, studies that seek to analyze molluscicidal activity from plant extracts have stood out. The present work aimed to obtain the phytochemical characterization and investigate the molluscicidal activity in the hydroalcoholic extract of Ricinus communis leaves on Biomphalaria glabrata. The hydroalcoholic extract was prepared by macerated with solvent ethanol P.A 96%, followed by filtration and concentration in rotary evaporator. Next, five groups of snails with 10 animals each, one being the negative control group, were submitted to treatments with four concentrations of 25, 50, 75 and 100 mg/L of hydroalcoholic extract of R. communis. The parameters mortality, physiological and behavioral aspects of mollusks were analyzed during 96h. The chemical characterization of the extract was performed by high-performance liquid chromatography coupled to mass spectrometry (LC-MS). Chemical characterization revealed the presence of tannins, flavonoids and ricinin alkaloid, but under the conditions analyzed, the presence of saponins was not observed. There was no significant molluscicidal activity of the extract. However, a greater influence was observed in the diet, in addition to the motility and physiological state of the snails (alteration of cephalopodal mass and oviposition). The toxicity test was performed with Artemia salina and no toxicity was observed for this microcrustacean. It is expected that the results obtained contribute to the fight against the expansion of schistosomiasis and that they make room for other studies that investigate the molluscicidal action of plant extracts.
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