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  • Title: Three New Selaginellin Derivatives from Selaginella pulvinata and Their α-Glucosidase Inhibitory Activity.
    Author: Zhu QF, Luo TT, Chen Q, Gao BB, Zeng AF, Ao JL, Xu GB, Liao SG, He X.
    Journal: Chem Biodivers; 2023 Apr; 20(4):e202300109. PubMed ID: 36786210.
    Abstract:
    Three new selaginellin derivatives, selaginpulvilins V-X (1-3), together with seven known analogs (4-10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR-ESI-MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol-trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α-glucosidase with IC50 values of 3.71, 2.04 and 4.00 μM, respectively.
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