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  • Title: Visual Detection and Sensing of Mercury Ions and Glutathione Using Fluorescent Copper Nanoclusters.
    Author: Zhang C, Liang M, Shao C, Li Z, Cao X, Wang Y, Wu Y, Lu S.
    Journal: ACS Appl Bio Mater; 2023 Mar 20; 6(3):1283-1293. PubMed ID: 36788220.
    Abstract:
    Visual detection of mercury ions and glutathione is of great significance to public health and environmental issues. Herein, we developed a fluorescent sensor (l-Cys/CuNCs@ESM) based on the eggshell membrane (ESM) and red-emitting copper nanoclusters (CuNCs) by the in situ strategy via l-cysteine (l-Cys) as the reducing and protective agent for mercury ions and glutathione sensing visually. The as-prepared fluorescent product had good stability, portability, large Stokes shift (250 nm), and long fluorescence lifetime (7.3 μs). Notably, the l-Cys/CuNCs@ESM exhibited a specific fluorescence quenching response toward Hg2+. Moreover, the interaction between glutathione (GSH) and Hg2+ could subsequently recover the fluorescence effectively. Inspired by this "on-off-on" switch, the l-Cys/CuNCs@ESM was applied as the dual-sensing system for visual detection of mercury ions and glutathione integrating with the portable smartphone. The limit of detection (LOD) of Hg2+ is 1.1 μM for visualization and 0.52 μM for the fluorescence spectrometer. The corresponding LODs of GSH are 2.8 and 0.59 μM, respectively. This platform presents significant sensitivity, specificity, and stability, offering a promising potential for real-time/on-site sensing.
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