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  • Title: Radioimaging of human ovarian carcinoma xenograft in nude mice.
    Author: Manetta A, Satyaswaroop PG, Hamilton T, Ozols R, Mortel R.
    Journal: Gynecol Oncol; 1987 Nov; 28(3):292-9. PubMed ID: 3678978.
    Abstract:
    Human ovarian carcinomas in nude mice were radioimaged using a well-characterized antibody against a tumor-associated antigen (CA 125) and three transplantable human ovarian carcinoma tumor lines: NIH:OVCAR 3, NIH:OVCAR 5, and NIH:OVCAR 9. Radioiodinated monoclonal antibody OC125 was used in these studies. In order to establish the optimal conditions for imaging, tumor/blood ratios were determined. Gamma scintigraphy of nude mice bearing subcutaneous transplants of human ovarian carcinomas 3-4 days after 131I-OC125 administration demonstrated selective localization of the radiolabeled monoclonal antibody by these tumors without need for any background subtraction techniques.
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