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  • Title: Activation of the human c-Ha-ras-1 proto-oncogene by in-vitro reaction with N-nitrosomethyl(acetoxymethyl)amine.
    Author: Hirani-Hojatti S, Milligan JR, Archer MC.
    Journal: IARC Sci Publ; 1987; (84):26-9. PubMed ID: 3679380.
    Abstract:
    Reaction of N-nitrosomethyl(acetoxymethyl)amine in vitro in the presence of esterase with a plasmid containing the human c-Ha-ras-1 gene has been shown to generate a transforming oncogene when the methylated DNA is transfected into NIH 3T3 cells. Our results show that an activated nitrosamine can mutate a normal cellular proto-oncogene, a reaction that may be the necessary first step in the multistage process of tumour induction.
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