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  • Title: Tubulointerstitial Nephritis and Uveitis Syndrome in the United Arab Emirates.
    Author: Pichi F, Aljeneibi S, Neri P.
    Journal: Ocul Immunol Inflamm; 2024 Jul; 32(5):578-582. PubMed ID: 36794345.
    Abstract:
    PURPOSE: To report the first series of tubulointerstitial nephritis (TINU) syndrome from the Middle East. METHODS: We retrospectively included patients with elevated urine beta-2 microglobulin, and a diagnosis of TINU based on anterior uveitis with or without posterior involvement. Multimodal imaging, duration of follow-up, local and systemic treatment used were recorded. RESULTS: 24 eyes of 12 patients (8 male, mean age 20.3 years) met the criteria for TINU. The most common posterior segment clinical finding was optic nerve head edema (41.7%), while on fluorescein angiography 58.3% and 75% of eyes had peripheral vascular and optic disc leakage, respectively. The mean follow-up was 2.5 years and all patients required immunomodulatory treatment. CONCLUSIONS: Middle Eastern patients with TINU seem to have a male predominance, a bimodal distribution in terms of age, and present with ocular involvement first. Multimodal imaging is paramount in detecting subclinical inflammation and tailoring immunomodulatory treatment.
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