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  • Title: Beta-oxidation of N-nitrosodiethanolamine in different animal species in vitro and in vivo.
    Author: Bonfanti M, Magagnotti C, Fanelli R, Airoldi L.
    Journal: IARC Sci Publ; 1987; (84):91-3. PubMed ID: 3679447.
    Abstract:
    The metabolism of N-nitrosodiethanolamine (NDELA) was studied to assess whether the formation of the beta-oxidized metabolites, N-nitroso(2-hydroxyethyl) (formylmethyl)amine (NHEFMA) and N-nitroso(2-hydroxyethyl)(carboxymethyl)amine (NHECMA), is involved in tumour induction in various animal species with different susceptibilities to NDELA carcinogenicity. In-vitro and in-vivo studies showed that all the animal species considered metabolize NDELA through the beta-oxidation pathway, suggesting that there is no correlation between carcinogenesis by NDELA and its beta-oxidation.
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