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  • Title: New tylosin analogs produced by mutants of Streptomyces fradiae.
    Author: Kiyoshima K, Takada K, Yamamoto M, Kubo K, Okamoto R, Fukagawa Y, Ishikura T, Naganawa H, Sawa T, Takeuchi T.
    Journal: J Antibiot (Tokyo); 1987 Aug; 40(8):1123-30. PubMed ID: 3680024.
    Abstract:
    2'''-Demethoxytylosin (component IIIc), 2'''-demethoxy-4'''-epi-tylosin (component IIId) and 2'''-O-demethyltylosin (component Vb) were produced by blocked mutant strains of Streptomyces fradiae. Fermentation, isolation, structure determination and biosynthetic considerations of these tylosin analogs are described.
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