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  • Title: Cloning of whiG, a gene critical for sporulation of Streptomyces coelicolor A3(2).
    Author: Mendez C, Chater KF.
    Journal: J Bacteriol; 1987 Dec; 169(12):5715-20. PubMed ID: 3680175.
    Abstract:
    In whiG mutants of Streptomyces coelicolor A3(2), aerial hyphae do not show any sign of sporulation. A library of S. coelicolor DNA was prepared in a phi C31 temperate phage vector (KC516), and one recombinant phage (KC750) that could restore the wild-type phenotype to a collection of whiG mutants when integrated into their genomes was found. Subcloning experiments with low- and high-copy-number Streptomyces plasmid vectors allowed partial localization of whiG in the cloned DNA and revealed that hypersporulation was associated with the presence of extra copies of whiG.
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