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  • Title: The penetration of antibiotics into the normal intervertebral disc.
    Author: Gibson MJ, Karpinski MR, Slack RC, Cowlishaw WA, Webb JK.
    Journal: J Bone Joint Surg Br; 1987 Nov; 69(5):784-6. PubMed ID: 3680343.
    Abstract:
    The role of antibiotics in the treatment of disc-space infection is controversial. This study assessed the tissue penetration of flucloxacillin and cephradine into the normal intervertebral disc after intravenous administration of a bolus dose of antibiotic. Twenty-five discs were removed from 12 adolescent patients having anterior spinal surgery to correct scoliosis; antibiotic had been administered between 30 minutes and four hours before operation. Despite high blood levels, no antibiotic could be detected by bioassay or by high-pressure liquid chromatography (h.p.l.c.) in any of the specimens from the nucleus pulposus or the annulus fibrosus.
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