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  • Title: Accumulation of peptidyl tRNA is lethal to Escherichia coli.
    Author: Menninger JR.
    Journal: J Bacteriol; 1979 Jan; 137(1):694-6. PubMed ID: 368041.
    Abstract:
    A mutant strain of Escherichia coli with temperature-sensitive peptidyl-tRNA hydrolase grows at 30 degrees C but, when shifted to 40 degrees C, dies at rates affected by physiological, pharmacological, and genetical perturbations. The rate of killing correlates with the relative accumulation of peptidyl-tRNA, suggesting that it is responsible for the death of the cells.
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