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  • Title: A paradigm for determination of direct drug-induced modulatory alterations in Purkinje cell activity during treadmill locomotion.
    Author: Smith SS, Chapin JK.
    Journal: J Neurosci Methods; 1987 Oct; 21(2-4):335-44. PubMed ID: 3682882.
    Abstract:
    This paper describes a paradigm employing chronic single unit recording techniques and videotape analysis of treadmill locomotion in order to determine drug-induced modulation of sensorimotor neuronal activity. Animals implanted with a chronic headstage microdrive unit and an indwelling jugular cannula are trained to walk on a treadmill (10 s on, 10 s off). Characteristically, cerebellar Purkinje cells recorded 1-1.5 mm from midline, exhibit increased rates of discharge in phase with movement of specific limbs during a particular stage of the step-swing cycle, as assessed by video analysis of locomotor patterns. Drug-induced alterations in this movement-correlated discharge relative to changes in the spontaneous firing rate can then be determined to assess drug-induced neuromodulatory effects beyond general non-specific excitatory or inhibitory actions.
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