These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clonidine and the hyper-responsiveness of dorsal horn neurones following morphine withdrawal in the spinal cat.
    Author: Zhao ZQ, Duggan AW.
    Journal: Neuropharmacology; 1987 Oct; 26(10):1499-502. PubMed ID: 3683764.
    Abstract:
    In barbiturate-anaesthetized spinal cats, exaggerated responses of dorsal horn neurones to impulses in unmyelinated primary afferents, were produced by administering naloxone after iontophoretic administration of morphine in the substantia gelatinosa. Clonidine, given both intravenously (5-10 micrograms/kg) and iontophoretically into the substantia gelatinosa, reduced cell responses to pre-naloxone values. The action of clonidine was reversed by idazoxan. This spinal action of clonidine may be an important component in the suppression of the opiate withdrawal syndrome observed in the whole animal.
    [Abstract] [Full Text] [Related] [New Search]