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Title: The significance of residual tumor after preoperative pelvic irradiation for stage II endometrial carcinoma. Author: Larson DM, Copeland LJ, Gallager HS, Wharton JT, Gershenson DM, Rutledge FN. Journal: Obstet Gynecol; 1987 Dec; 70(6):916-9. PubMed ID: 3684130. Abstract: The prognostic significance of residual endometrial carcinoma in the hysterectomy specimen after preoperative radiotherapy is controversial. Sixty-two patients with stage II endometrial carcinoma were treated with a standardized program of preoperative radiotherapy, followed in six weeks by an extrafascial hysterectomy. Twenty patients (32%) had no residual carcinoma in their hysterectomy specimens and 42 (68%) had residual carcinoma. There were no significant clinical, surgical, or pathologic differences between patients with or without residual carcinoma. Patients with no residual carcinoma had a 25% recurrence rate and a 53% actuarial five-year survival rate. Patients with residual carcinoma had a 21% recurrence rate and a 78% actuarial five-year survival rate. The presence of residual endometrial carcinoma in the hysterectomy specimen does not imply a compromised prognosis in patients with stage II endometrial carcinoma treated by the described method.[Abstract] [Full Text] [Related] [New Search]