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  • Title: Characteristics and health risk assessment of volatile N-nitrosamines in the plasma of adults in Guangdong Province, China.
    Author: Lin S, Wang H, Cai L, Liao L, Su Y, Cai X, Shen M.
    Journal: J Pharm Biomed Anal; 2023 Apr 01; 227():115189. PubMed ID: 36854220.
    Abstract:
    N-nitrosamines are strong carcinogens that are widely present in the environment. This study developed a method, and analyzed the concentrations of volatile N-nitrosamines (VNAs) in the plasma of adults in Guangdong Province, China. Finally, the health risks to adults in Guangdong Province, China, with dietary exposure to VNAs were assessed. Gas chromatography/mass spectrometry (GC/MS) in electron impact (EI) ionization source mode was used to quantitatively analyze VNAs, and to perform accurate mass determination. The lower limit of detection (LOD) of nine nitrosamines are ranged from 0.01 to 2.14 ng/mL. The recovery rate ranged from 83 % to 116 %, and the relative standard deviation (RSD) was < 10 %. The method developed is simple, rapid, and provides good reproducibility and high sensitivity. N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), N-nitrosodinbutylamine (NDBA), N-nitrosopiperidine (NPIP), N-nitrosopyrrolidine (NPYR), N-nitrosomorpholine (NMOR) and N-nitrosodiphenylamine (NDPhA) were detected in 92 adult plasma samples. NDMA and NMEA were detected in 56.5 % and 44.6 % of the samples, followed by NPIP (34.8 %). NDMA had the highest median concentration (43.7 ng/mL) in the total samples. There were gender-related differences found in the concentrations of NDBA and NDPhA. The exposure risk assessment results showed that the two highest daily dietary intakes of VNAs were N-nitrosodi-n-propylamine (NDPA) and NDMA, and aquatic products and pickled vegetables contributed the most total nitrosamine intake. The lifetime cancer risk of adults ranged from 2.88 × 10-10 to 7.46 × 10-5, and the risk associated with NDMA, NDPA, N-nitrosodiethylamine (NDEA), NMEA and NPIP are important and should attract more attention. This study aimed to explore the exposure levels of VNAs in the plasma of adults in Guangdong Province, China, and to assess the health risks of dietary intake of VNAs, which provides a basis of the effect of VNAs exposure on human health.
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