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  • Title: Lethal hyperparathyroid crisis: hazards of phosphate administration.
    Author: Vernava AM, O'Neal LW, Palermo V.
    Journal: Surgery; 1987 Dec; 102(6):941-8. PubMed ID: 3686357.
    Abstract:
    Two patients with hypercalcemia crisis and parathyroid adenoma died as a result of pulmonary insufficiency. The administration of phosphate is believed to have contributed to the deaths, since the pulmonary problems appeared when the blood [Ca] X [PO4] product rose and extensive metastatic calcification was present in the pulmonary alveolar lining. The use of phosphates as calcium-lowering agents in hypercalcemia is discouraged, because phosphate appears to lower calcium levels only by intravascular precipitation.
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