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  • Title: Accounting for word production, comprehension, and repetition in semantic dementia, Alzheimer's dementia, and mild cognitive impairment.
    Author: Roelofs A.
    Journal: Brain Lang; 2023 Mar; 238():105243. PubMed ID: 36868157.
    Abstract:
    It has been known since Pick (1892, 1904) that word retrieval is commonly impaired in left temporal lobe degeneration. Individuals with semantic dementia (SD), Alzheimer's dementia (AD), and mild cognitive impairment (MCI) present with word retrieval difficulty, while comprehension is less affected and repetition is preserved. Whereas computational models have elucidated performance in poststroke and progressive aphasias, including SD, simulations are lacking for AD and MCI. Here, the WEAVER++/ARC model, which has provided neurocognitive computational accounts of poststroke and progressive aphasias, is extended to AD and MCI. Assuming a loss of activation capacity in semantic memory in SD, AD, and MCI, the simulations showed that severity variation accounts for 99% of the variance in naming, comprehension, and repetition at the group level and 95% at the individual patient level (N = 49). Other plausible assumptions do less well. This supports a unified account of performance in SD, AD, and MCI.
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