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  • Title: [Rational combinations of hormonal and cytostatic agents in disseminated forms of breast cancer].
    Author: Garin AM, Dmitrieva NV, Vyshinskaia GV, Lichintser MR.
    Journal: Vopr Onkol; 1987; 33(11):13-7. PubMed ID: 3686916.
    Abstract:
    The report deals with the results of chemotherapy of 25 cases of advanced breast cancer. The patients had received tamoxifen + diethylstilbestrol (or chlorotrianizen) to stimulate a short-term proliferation in tumor and to potentiate the effect of cytostatic drugs. Complete regression of tumor was observed in I case and partial regression--in 12 cases (overall response--52%). Tumor growth stimulation effect was assessed on the basis of changes in DNA synthesis rate and proliferative pool as evidenced by repeated biopsy of tumor.
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