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  • Title: Vitamin A status of preterm infants: correlation between plasma retinol concentration and retinol dose response.
    Author: Woodruff CW, Latham CB, Mactier H, Hewett JE.
    Journal: Am J Clin Nutr; 1987 Dec; 46(6):985-8. PubMed ID: 3687827.
    Abstract:
    Retinol dose response tests were performed on 83 preterm infants shortly before discharge by giving orally 5000 IU of an aqueous dispersion of retinol. Predose plasma retinol concentrations were 2.5-20.5 micrograms/dL (0.087-0.72 mumol/L) and the retinol dose responses were 0-59.8%. The regression of retinol dose response on predose retinol was -0.58. There was a parallel increase in both retinol and retinol-binding protein and an increase in the molar ratio of retinol-binding protein to prealbumin. Prealbumin did not increase. These findings suggest that preterm infants have reduced liver stores of vitamin A.
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