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  • Title: Five New Phenolic Glycosides from Viburnum luzonicum.
    Author: Chen J, Zhao M, Zhou H, Tang Y, Ji W, Shao J, Zhao C, Zhao C.
    Journal: Chem Biodivers; 2023 Apr; 20(4):e202300246. PubMed ID: 36896855.
    Abstract:
    Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α-amylase and α-glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A-E (1-5), were obtained by bioassay-guided isolation coupled with HPLC-QTOF-MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α-amylase and α-glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α-amylase (IC50 =17.5 μM) and α-glucosidase (IC50 =13.6 μM).
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