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  • Title: [Change in tissue glycogen reserves in tumor bearers as a reflection of a hypoglycemic stress syndrome].
    Author: Chekulaev VA, Shelepov VP, Pasha-Zade GR, Shapot VS.
    Journal: Biull Eksp Biol Med; 1987 Dec; 104(12):720-2. PubMed ID: 3689968.
    Abstract:
    Glycogen content in the brain, liver and skeletal muscles of rats bearing ascite Zajdela hepatoma (AZH) and solid 27 hepatoma (27-H) has been studied. Serum glucose levels directly correlated with liver glycogen reserves. In the terminal stage of tumor growth depletion of liver glycogen was observed, while the stores of muscle glycogen did not diminish. Within 1-4 days (AZH) and 15-30 days (27-H) after implantation the stores even exceeded those of control healthy rats. In the terminal stage, in spite of hypoglycaemia development, the content of brain glycogen was significantly elevated in both groups of animals.
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