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  • Title: Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma.
    Author: Lan TL, Lin CF, Lee YY, Lin KH, Chang FC, Lin SC, Lee JC, Chou FI, Peir JJ, Liu HM, Mu PF, Chen YW.
    Journal: Int J Mol Sci; 2023 Mar 04; 24(5):. PubMed ID: 36902408.
    Abstract:
    Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas.
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