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  • Title: Phorbol esters stimulate 2-deoxyglucose uptake in glia, but not neurons.
    Author: Clarke D, Ramaswamy A, Holmes L, Mudd L, Poulakos J, Raizada MK.
    Journal: Brain Res; 1987 Sep 22; 421(1-2):358-62. PubMed ID: 3690278.
    Abstract:
    Activation of protein kinase C by phorbol esters caused a time- and dose-dependent stimulation (270% of control) of glucose uptake in cultured glia, but not in neurons from rat brain. The phorbol ester stimulation of Vmax of glial glucose uptake occurred only in glia despite nearly 2.5-fold greater phorbol ester binding in neurons. These differences in cellular responses to protein kinase C activation may be the key to understanding brain glucose regulation.
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