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  • Title: Rapid kindling in the prepubescent rat.
    Author: Holmes GL, Thompson JL.
    Journal: Brain Res; 1987 Dec 01; 433(2):281-4. PubMed ID: 3690337.
    Abstract:
    Bipolar electrodes, stereotaxically implanted in the hippocampus and amygdala of prepubescent rats, were used to deliver 1- or 10-s trains of suprathreshold bipolar stimulations at frequencies of 10 or 60 Hz. The stimuli were administered every 5 min. Rapid kindling was achieved with 10-s but not 1-s stimulation with both 10- and 60-Hz frequencies. Ten-s stimulations with a 60-Hz frequency resulted in more rapid kindling than 10-s stimulations with a 10-Hz frequency. The rate of kindling was similar in the hippocampus and amygdala. In the immature animal rapid kindling can be achieved with electrical stimulations with long duration and short interstimulus intervals.
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