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  • Title: [Nature of the immunotropic activity of calcium antagonists].
    Author: Iampol'skiĭ VS, Ratnikov VI.
    Journal: Farmakol Toksikol; 1987; 50(5):43-5. PubMed ID: 3691776.
    Abstract:
    It was shown in experiments on CBA mice that four-fold administration of calcium antagonists (verapamil, nifedipine) in doses of 5-10 mg/kg was accompanied by the development of the immunosuppressive effect. Reactions of hypersensitivity of delayed type were inhibited to the greatest degree. To a lesser degree calcium antagonists suppressed the humoral immune responses to the thymus-dependent antigen without exerting any action on the formation of antibodies to the thymus-independent antigen.
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