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  • Title: Research on antibacterial and antifungal agents. III. Synthesis and antimicrobial activity of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolylmethyl-5-aryl furans.
    Author: Porretta GC, Scalzo M, Chimenti F, Bolasco A, Biava M, Fischetti M, Riccardi F.
    Journal: Farmaco Sci; 1987 Sep; 42(9):629-39. PubMed ID: 3691788.
    Abstract:
    The synthesis and microbiological activities of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolyl-methyl-5-aryl-3-furans are reported. Antimicrobial data in comparison with pyrrolnitrin showed an interesting antifungal activity but a very poor antibacterial activity. The presence of an imidazole nucleus does not increase antifungal activity. The introduction of a substituent in the para position of the aryl at a C5 of the furan ring affects antifungal activity.
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