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  • Title: Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VIII.
    Author: Longobardi M, Bargagna A, Schenone P, De Santis D, Angrisani M, Marmo E.
    Journal: Farmaco Sci; 1987 Sep; 42(9):691-6. PubMed ID: 3691791.
    Abstract:
    The synthesis of some alkyl, aryl thioureas and aryl ureas starting from 5-trans-(3-aminopropoxy)-1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octane is described. Some thioureas showed a remarkable antiarrhythmic activity besides a weak hypotensive effect in rats and, like some ureas, infiltration anesthesia in mice.
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