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  • Title: On the role of microsomal aldehyde dehydrogenase in metabolism of aldehydic products of lipid peroxidation.
    Author: Antonenkov VD, Pirozhkov SV, Panchenko LF.
    Journal: FEBS Lett; 1987 Nov 30; 224(2):357-60. PubMed ID: 3691794.
    Abstract:
    To elucidate a possible role of membrane-bound aldehyde dehydrogenase in the detoxication of aldehydic products of lipid peroxidation, the substrate specificity of the highly purified microsomal enzyme was investigated. The aldehyde dehydrogenase was active with different aliphatic aldehydes including 4-hydroxyalkenals, but did not react with malonic dialdehyde. When Fe/ADP-ascorbate-induced lipid peroxidation of arachidonic acid was carried out in an in vitro system, the formation of products which react with microsomal aldehyde dehydrogenase was observed parallel with malonic dialdehyde accumulation.
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