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  • Title: Immunosuppressive activity of 15-deoxyspergualin and its effect on skin allografts in rats.
    Author: Masuda T, Mizutani S, Iijima M, Odai H, Suda H, Ishizuka M, Takeuchi T, Umezawa H.
    Journal: J Antibiot (Tokyo); 1987 Nov; 40(11):1612-8. PubMed ID: 3693129.
    Abstract:
    The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented. These compounds suppressed antibody formation and establishment of delayed-type hypersensitivity to sheep red blood cells (SRBC) in mice. Among spergualin, 15-deoxyspergualin, and N-30, 15-deoxyspergualin was most effective in suppressing immune responses. It suppressed antibody formation against SRBC by spleen cell cultures in a dose-dependent fashion without reducing cell viability. The spergualins also suppressed the mixed lymphocyte culture reaction. Peritoneal exudate cells taken from mice given immunosuppressive doses of 15-deoxyspergualin were not reduced in their functions measured: Release of lysosomal enzymes and production of superoxide anions. 15-Deoxyspergualin and N-30 were markedly effective in prolonging skin graft in rats.
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