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  • Title: DMSO potentiates aminonucleoside of puromycin nephrosis in rats.
    Author: Spear GS, Nguyen D, Conklin S, Wikle JS, Fan J, Lan YH, Allen J, Reineck S.
    Journal: J Pathol; 1987 Oct; 153(2):183-7. PubMed ID: 3694323.
    Abstract:
    Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague-Dawley rats. The effect was evident at 4 as well as 8-9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.
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