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  • Title: Synovitis in secondary syphilis. Clinical, light, and electron microscopic studies.
    Author: Reginato AJ, Schumacher HR, Jimenez S, Maurer K.
    Journal: Arthritis Rheum; 1979 Feb; 22(2):170-6. PubMed ID: 369568.
    Abstract:
    Polyarthritis and tenosynovitis were seen as the presenting complaints in 7 patients with secondary syphilis. Synovial needle biopsy was obtained in 3 cases and showed mild synovitis with infiltration by lymphocytes, plasma cells, and polymorphonuclear leukocytes; vascular congestion; and slightly increased synovial lining cells. In addition, electron microscopy in these synovial membranes showed many necrotic polymorphonuclear leukocytes, much interstitial debris and fibrin, and in 2 patients, bodies suggestive of Treponema pallidum in the interstitium and in vessel lumens.
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